Interchromosomal clustering of active genes at the nuclear pore complex
نویسندگان
چکیده
منابع مشابه
Transcriptional regulation at the nuclear pore complex.
The nonrandom spatial distribution of chromosomes and genes in the eukaryotic nucleus has been appreciated for decades, although a detailed understanding of the functional role of such positioning has remained illusive. The most prominent structural feature of the nucleus is the nuclear periphery, classically considered as a zone of gene repression caused by the presence of heterochromatin and ...
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Airport security checkpoints might take a lesson from the nuclear pore complex (NPC), where, according to Dange et al., there are no long lines and no slowdown despite the hubbub around them. The group used single-molecule video microscopy, with a localization precision of about the width of a protein, to track single molecules of labeled, cargo-carrying receptors entering the NPC in vivo. They...
متن کاملThe nuclear pore complex
M OLECULAR trafficking between the nucleus and the cytoplasm of interphase eukaryotic cells occurs via the nuclear pore complexes (NPCs), 1 organelles with a roughly cylindrical shape (~,120 um in diameter and ~70-um high) that are embedded in the double-membraned nuclear envelope (NE). The NPC allows passive diffusion of ions and small molecules through an aqueous channel with a physical diame...
متن کاملThe nuclear pore complex.
Over the past years, significant progress has been made both in the analysis of the structural and molecular organization of the nuclear pore complex (NPC) and the mechanism of nuclear transport. In this minireview, I will focus on some of the recent developments in this field. Structural studies employing high resolution EM have revealed a detailed view of the three-dimensional organization of...
متن کاملDeciphering networks of protein interactions at the nuclear pore complex.
The nuclear pore complex (NPC) gates the only known conduit for molecular exchange between the nucleus and cytoplasm of eukaryotic cells. Macromolecular transport across the NPC is mediated by nucleocytoplasmic shuttling receptors termed karyopherins (Kaps). Kaps interact with NPC proteins (nucleoporins) that contain FG peptide repeats (FG Nups) and altogether carry hundreds of different cargoe...
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ژورنال
عنوان ژورنال: Nucleus
سال: 2012
ISSN: 1949-1034,1949-1042
DOI: 10.4161/nucl.22663